Pesquisas — Artigos Científicos

Conheça os principais estudos e artigos científicos que fundamentam a seleção dos 11 ingredientes presentes no Ovacare SOMP, um suplemento que reúne mio-inositol, NAC, Coenzima Q10, vitaminas e minerais em uma única dose diária, desenvolvida para simplificar o cuidado com a saúde feminina.

Clique nos títulos para acessar as publicações científicas originais.

MIO-INOSITOL 

1. Teede HJ, et al. (2023). Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. European Journal of Endocrinology.

2. Costantino D, et al. (2009). Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. European Review for Medical and Pharmacological Sciences, 13(2), 105–110.

3. Genazzani AD, et al. (2008). Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecological Endocrinology, 24(3), 139–144.

4. Sigue & Decena (2022). Efficacy of Myo-inositol in Improving Pregnancy Rate and Regulation of Menstrual Cycle for Patients With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.

L-METILFOLATO 

1. National Institutes of Health (NIH), Office of Dietary Supplements. Folate: Fact Sheet for Health Professionals. Aborda a importância do folato na divisão celular, síntese de DNA, formação das células vermelhas do sangue, metabolismo da homocisteína e desenvolvimento fetal.

2. Lamers Y, et al. (2006). Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age. The American Journal of Clinical Nutrition, 84(1), 156–161.

3. Lamers Y, et al. (2004). Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. The American Journal of Clinical Nutrition, 79(3), 473–478.

4. Supplementation with (6S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolised folic acid in maternal plasma: a randomised trial of pregnant women in Canada. (2024). British Journal of Nutrition.

5. Crider KS, et al. (2022). Folic Acid and the Prevention of Birth Defects: 30 Years of Opportunity and Controversies. Annual Review of Nutrition, 42, 423–452.

PICOLINATO DE CROMO 

1. National Institutes of Health (NIH), Office of Dietary Supplements. Chromium: Fact Sheet for Health Professionals. Referência sobre as funções metabólicas do cromo, sua relação com a insulina, fontes alimentares, suplementação e segurança.

2. Hamsho M, Ranneh Y, Fadel A. (2025). Therapeutic effects of chromium supplementation on women with polycystic ovarian syndrome: A systematic review and meta-analysis. Endocrinología, Diabetes y Nutrición, 72(8), 501578.

3. Georgaki MN, et al. (2024). Chromium supplementation and type 2 diabetes mellitus: an extensive systematic review. Environmental Geochemistry and Health, 46, artigo 515.

4. Brownley KA, et al. (2013). A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study. Journal of Psychosomatic Research, 75(1), 36–42.

MAGNÉSIO 

1. National Institutes of Health (NIH), Office of Dietary Supplements. Magnesium: Fact Sheet for Health Professionals. Referência sobre metabolismo energético, funcionamento muscular e neuromuscular, saúde óssea e funções celulares do magnésio.

2. Walker AF, et al. (1998). Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of Women's Health, 7(9), 1157–1165.

3. De Souza MC, et al. (2000). A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of Women's Health & Gender-Based Medicine, 9(2), 131–139.

4. Dominguez LJ, et al. (2023). Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients, 15(6), 1304.

VITAMINA D

1. National Institutes of Health (NIH), Office of Dietary Supplements. Vitamin D: Fact Sheet for Health Professionals. Referência sobre absorção de cálcio e fósforo, saúde óssea, funcionamento muscular, sistema imunológico e metabolismo da vitamina D.

2. Han Y, et al. (2023). Effect of vitamin D supplementation on hormones and menstrual cycle regularization in polycystic ovary syndrome women: A systematic review and meta-analysis. Journal of Obstetrics and Gynaecology Research, 49(9), 2232–2244.

3. Kohlhoff G, Kirwan R, Mushtaq S. (2024). The effect of vitamin D supplementation on markers of insulin resistance in women with polycystic ovarian syndrome: a systematic review. European Journal of Nutrition, 63, 2859–2869.

4. Yin T, et al. (2024). Effect of vitamin D supplementation on lipid profile, and hormonal functions in polycystic ovary syndrome: An umbrella systematic review and meta-analysis. Prostaglandins & Other Lipid Mediators.

ZINCO 

1. National Institutes of Health (NIH), Office of Dietary Supplements. Zinc: Fact Sheet for Health Professionals. Referência sobre as funções do zinco na proteção antioxidante, síntese de proteínas e DNA, divisão celular, imunidade e saúde da pele.

2. Jamilian M, et al. (2016). Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial. Biological Trace Element Research, 170(2), 271–278.

3. National Institutes of Health (NIH), Office of Dietary Supplements. Dietary Supplements for Immune Function and Infectious Diseases: Fact Sheet for Health Professionals. Referência sobre o papel do zinco no funcionamento do sistema imune e na manutenção das barreiras protetoras do organismo.

4. National Institutes of Health (NIH), Office of Dietary Supplements. Dietary Supplements and Life Stages: Pregnancy. Fact Sheet for Health Professionals. Referência sobre a importância do zinco na gestação, divisão celular e desenvolvimento fetal.

NAC 

1. Viña I, et al. (2025). Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis. Nutrients, 17(2), 284.

2. Liu J, et al. (2023). The effects of N-acetylcysteine supplement on metabolic parameters in women with polycystic ovary syndrome: a systematic review and meta-analysis. Frontiers in Nutrition, 10, 1209614.

3. Shahveghar Asl Z, Parastouei K, Eskandari E. (2023). The effects of N-acetylcysteine on ovulation and sex hormones profile in women with polycystic ovary syndrome: a systematic review and meta-analysis. British Journal of Nutrition, 130(2), 202–210.

4. Thakker D, Raval A, Patel I, Walia R. (2015). N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Obstetrics and Gynecology International, 2015, 817849.

5. Schwalfenberg GK. (2021). N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks). Journal of Nutrition and Metabolism, 2021, 9949453.

COENZIMA Q10 

1. National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health (NIH). Coenzyme Q10. Referência sobre as funções da CoQ10 no organismo, sua participação na produção de energia celular e as evidências sobre suplementação.

2. Zhang T, et al. (2023). Efficacy and Safety of Coenzyme Q10 Supplementation in the Treatment of Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis. Reproductive Sciences, 30(4), 1033–1048.

3. Zhang J, et al. (2021). The effectiveness of coenzyme Q10, vitamin E, inositols, and vitamin D in improving the endocrine and metabolic profiles in women with polycystic ovary syndrome: a network Meta-analysis. Gynecological Endocrinology, 37(12), 1063–1071.

4. Lin G, et al. (2024). Clinical evidence of coenzyme Q10 pretreatment for women with diminished ovarian reserve undergoing IVF/ICSI: a systematic review and meta-analysis. Annals of Medicine, 56(1), 2389469.

5. Florou P, et al. (2020). Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials. Journal of Assisted Reproduction and Genetics, 37(10), 2377–2387.

VITAMINA B6 

1. National Institutes of Health (NIH), Office of Dietary Supplements. Vitamin B6: Fact Sheet for Health Professionals. Referência sobre metabolismo energético, funcionamento do sistema nervoso, formação da hemoglobina, função imunológica e metabolismo da homocisteína.

2. Wyatt KM, et al. (1999). Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ, 318(7195), 1375–1381.

3. Kashanian M, et al. (2007). Pyridoxine (vitamin B6) therapy for premenstrual syndrome. International Journal of Gynecology & Obstetrics, 96(1), 43–44.

VITAMINA E

1. National Institutes of Health (NIH), Office of Dietary Supplements. Vitamin E: Fact Sheet for Health Professionals.

2. Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta-analysis. (2022). Scientific Reports, 12, 5770.

3. Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials. (2022). Gynecological Endocrinology.

4. A meta-analysis of effects of vitamin E supplementation alone and in combination with omega-3 or magnesium on polycystic ovary syndrome. (2022). Revisão sistemática e meta-análise de ensaios clínicos sobre parâmetros metabólicos, hormonais e inflamatórios em mulheres com SOP.

SELÊNIO 

1. National Institutes of Health (NIH), Office of Dietary Supplements. Selenium: Fact Sheet for Health Professionals. 

2. Zhao J, et al. (2023). Effects of selenium supplementation on Polycystic Ovarian Syndrome: a systematic review and meta-analysis on randomized clinical trials. BMC Endocrine Disorders, 23, 33.

3. Effect of Selenium Supplementation on Biochemical Markers of Women with Polycystic Ovarian Syndrome: A Systematic Review. (2023). 

4. Wu PY, et al. (2022). Selenium supplementation for polycystic ovary syndrome: a meta-analysis of randomized controlled trials. Gynecological Endocrinology, 38(11), 928–934.

5. Selenium and Polycystic Ovary Syndrome; Current Knowledge and Future Directions: A Systematic Review. (2019). 

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COMPRAR AGORA 

As referências apresentadas abordam ingredientes e mecanismos específicos. O Ovacare SOMP é um suplemento alimentar e não se destina a prevenir, tratar ou curar doenças.